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教員紹介

古泉 博之 准教授 [Hiroyuki Koizumi]

担当授業科目
生物学Ⅰ,Ⅱ/生化学Ⅱ,/Ⅲ/分子生物学/細胞生物学/基礎科学演習Ⅰ/薬学基礎実習/生物系実習Ⅰ,/Ⅱ/特別実習
主な研究
主な研究テーマ
  1. 神経回路形成に関わるダブルコルチン様キナーゼの分子メカニズムの解明
  2. 発達障害モデルマウスを用いた衝動性の神経基盤の解明
研究論文
  1. Koizumi H*, Fujioka H, Togashi K, Thompson J, Yates JR, 3rd, Gleeson JG, Emoto K*: DCLK1 phosphorylates the microtubule-associated protein MAP7D1 to promote axon elongation in cortical neurons. Dev Neurobiol 77:493-510 (2017)
  2. Shin E, Kashiwagi Y, Kuriu T, Iwasaki H, Tanaka T, Koizumi H, Gleeson JG, Okabe S*: Doublecortin-like kinase enhances dendritic remodeling and negatively regulates synapse maturation. Nature Commun 4:1440 (2013)
  3. Kerjan G, Koizumi H, Han EB, Dube CM, Djakovic SN, Patrick GN, Baram TZ, Heinemann SF, Gleeson JG*: Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Proc Natl Acad Sci U S A 106:6766-6771 (2009)
  4. Yamaguchi N, Koizumi H, Aoki J, Natori Y, Nishikawa K, Natori Y, Takanezawa Y, Arai H*: Type I platelet-activating factor acetylhydrolase catalytic subunits over-expression induces pleiomorphic nuclei and centrosome amplification. Genes Cells 12:1153-1161 (2007)
  5. Koizumi H, Higginbotham H, Poon T, Tanaka T, Brinkman BC, Gleeson JG*: Doublecortin maintains bipolar shape and nuclear translocation during migration in the adult forebrain. Nature Neurosci 9: 779-786 (2006)
  6. Tanaka T, Koizumi H, Gleeson JG*: The doublecortin and doublecortin-like kinase 1 genes cooperate in murine hippocampal development. Cereb Cortex 16 Suppl 1:i69-73 (2006)
  7. Koizumi H, Tanaka T, Gleeson JG*: Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration. Neuron 49: 55-66 (2006)
  8. Shibata M, Ishii J, Koizumi H, Shibata N, Dohmae N, Takio K, Adachi H, Tsujimoto M, Arai H*: Type F scavenger receptor SREC-I interacts with advillin, a member of the gelsolin/villin family, and induces neurite-like outgrowth. J Biol Chem 279:40084-40090 (2004)
  9. Yamaguchi N, Takanezawa Y, Koizumi H, Umezu-Goto M, Aoki J, Arai H*: Expression of NUDEL in manchette and its implication in spermatogenesis. FEBS Lett 566:71-76 (2004)
  10. Koizumi H, Yamaguchi N, Hattori M, Ishikawa TO, Aoki J, Taketo MM, Inoue K, Arai H*: Targeted disruption of intracellular type I platelet activating factor-acetylhydrolase catalytic subunits causes severe impairment in spermatogenesis. J Biol Chem 278:12489-12494 (2003)

所属学会・団体名
  • 北米神経科学会
  • 日本薬学会
  • 日本分子生物学会
  • 日本神経科学学会


奥羽大学

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