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教員紹介

守屋 孝洋 教授 [Takahiro Moriya]

担当授業科目
機能形態学Ⅰ/機能形態学Ⅱ/生物学Ⅱ/解剖学/薬と病態(薬理系14)/薬学基礎実習/生物系実習Ⅰ
主な研究
主な研究テーマ
  1. 体内時計の光環境適応機能を高める薬物および食品成分の作用機序の究明研究
  2. 細胞増殖と体内時計のクロストークの解明
  3. 末梢循環改善作用を示す健康食品成分の作用機序の解明研究
研究論文
  1. Mogi A, Yomoda R, Kimura S, Tsushima C, Takouda J, Sawauchi M, Maekawa T, Ohta H, Nishino S, Kurita M, Mano N, Osumi N, Moriya T: Entrainment of the circadian clock in neural stem cells by epidermal growth factor is closely associated with ERK1/2-mediated induction of multiple clock-related genes. Neuroscience 2018; 379: 45-66.
  2. Asakawa S, Onodera R, Kasai K, Kishimoto Y, Sato T, Segawa R, Mizuno N, Ogasawara K, Moriya T, Hiratsuka M, Hirasawa N: Nickel ions bind to HSP90β and enhance HIF-1α-mediated IL-8 expression. Toxicology 2018; 395:45-53.
  3. Segawa R, Shigeeda K, Hatayama T, Dong J, Mizuno N, Moriya T, Hiratsuka M, Hirasawa N: EGFR transactivation is involved in TNF-α-induced expression of thymic stromal lymphopoietin in human keratinocyte cell line. J Dermatol Sci 2018; 89: 290-298.
  4. Weng Y, Mizuno N, Dong J, Segawa R, Yonezawa T, Cha BY, Woo JT, Moriya T, Hiratsuka M, Hirasawa N: Induction of thymic stromal lymphopoietin by a steroid alkaloid derivative in mouse keratinocytes. Int Immunopharmacol 2018; 55: 28-37.
  5. Natsumi Mizuno, koudai Abe, Yukari Morishita, Saori Yamashita, Ryosuke Segawa, jiangxu Dong, Takahiro Moriya, Masahiro Hiratsuka and Noriyasu Hirasawa: Pentanoic acid induces thymic stromal lymphopoietin production through Gq/11 and Rho-associated protein kinase signaling pathway in keratinocytes. Int Immunopharmacol 2017; 50: 216-223.
  6. Okuda-Tanino A, Sugawara D, Tashiro T, Iwashita M, Obara Y, Moriya T, Tsushima C, Saigusa D, Tomioka Y, Ishii K, Nakahata N: Licochalcones extracted from Glycyrrhiza inflata inhibit platelet aggregation accompanied by inhibition of COX-1 activity. PLoS ONE 2017; 12(3): e0173628.
  7. Kurita M, Moriya T, Nishino S, Hirata E, Sato T, Okubo Y: Non-24-hour sleep-wake syndrome improved by low-dose valproic acid: a case report Non-24 improved by low-dose valproic acid. Neuropsychiatric Disease and Treatment. 2016; 12: 3199?3203.
  8. Nakagawasai O, Nemoto W, Onogi H, Moriya T, Lin J-R, Odaira T, Yaoita F, Ogawa T, Ohta K, Endo Y, Tan-No K: BE360, a new selective estrogen receptor modulator, produces antidepressant and antidementia effects through the enhancement of hippocampal cell proliferation in olfactory bulbectomized mice. Behavioural Brain Research 2016; 297: 315-22.
  9. ndo K, Fukuhara S, Moriya T, Obara Y, Nakahata N, Mochizuki N: Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization. J Cell Biol, 2013; 202: 901-916.
  10. Goto S, Saito M, Obara Y, Moriya T, Nakahata N: Involvement of lipid rafts in multiple signal transductions mediated by two isoforms of thromboxane A2 receptor: dependency on receptor isoforms and downstream signaling types. Eur J Pharmacol 2012; 693: 15-24.
  11. Nusuetrong P, Saito M, Kikuchi H, Oshima Y, Moriya T, Nakahata N: Apoptotic effects of satratoxin H is mediated through DNA double-stranded break in PC12 cells. Journal of Toxicological Sciences 2012; 37: 803-812.
  12. Suzuki T, Obara Y, Moriya T, Nakata H, Nakahata N: Functional interaction between purinergic receptors: effect of ligands for A2A and P2Y12 receptors on P2Y1 receptor function. FEBS Lett 2011; 585: 3978-3984.
  13. Sakayori N, Maekawa M, Numayama-Tsuruta K, Katura T, Moriya T, Osumi N. Distinctive effects of arachidonic acid and docosahexaenoic acid on neural stem/progenitor cells. Genes to Cells, 2011; 16: 778-790.
  14. Akiyama S, Ohta H, Watanabe S, Moriya T, Hariu A, Nakahata N, Chisaka H, Matsuda T, Kimura Y, Tsuchiya S, Tei H, Okamura K and Yaegashi N: The Uterus Sustains Stable Biological Clock during Pregnancy. Tohoku Journal of Experimental Medicine 2010; 221: 287-298.
  15. Katura T, Moriya T, Nakahata N: 15-Deoxy-Δ12,14-Prostaglandin J2 Biphasically Regulates the Proliferation of Mouse Hippocampal Neural Progenitor Cells by Modulating the Redox State. Mol Pharmacol 2010; 77: 601-611.
  16. Tahara Y, Hirao A, Moriya T, Kudo T, Shibata S: Effects of medial hypothalamic lesions on feeding-induced entrainment of locomotor activity and liver Per2 expression in Per2::luc mice. J Biol Rhythms 2010; 25: 9-18.
  17. Ikeda M, Hirono M, Sugiyama T, Moriya T, Ikeda-Sagara M, Eguchi N, Urade Y, Yoshioka T: Phospholipase C beta4 is essential for the progression of the normal sleep sequence and ultradian body temperature rhythms in mice. PLoS ONE 2009; 4: e7737.
  18. Tsutakawa S, Kobayashi D, Kusama M, Moriya T, Nakahata N: Nicotine enhances skin necrosis and expression of inflammatory mediators in a rat pressure ulcer model. Br J Dermatology 2009; 161: 1020-1027.
  19. Moriya T, Aida R, Kudo T, Akiyama M, Doi M, Hayasaka N, Nakahata N, Mistlberger R, Okamura H, Shibata S: The dorsomedial hypothalamic nucleus is not necessary for food-anticipatory circadian rhythms of behavior, temperature or clock gene expression in mice. Eur J Neurosci 2009; 29: 1447-1460.
  20. Ohta H, Xu S, Moriya T, Iigo M, Watanabe T, Nakahata N, Chisaka H, Hanita T, Matsuda,T Ohura T, Kimura Y, Yaegashi N, Tsuchiya S, Tei H, Okamura K: Maternal Feeding Controls Fetal Biological Clock. PLoS ONE 2008; 3: e2601.
  21. 15. Bastos GN, Moriya T, Inui F, Katsura T, Nakahata N: Involvement of cyclooxygenase-2 in lipopolysaccharide-induced impairment of the newborn cell survival in the adult mouse dentate gyrus. Neuroscience 2008; 155: 454-462.
  22. Horie N, So K, Moriya T, Kitagawa N, Tsutsumi K, Nagata I, Shinohara K: Effects of Oxygen Concentration on the Proliferation and Differentiation of Mouse Neural Stem Cells In Vitro. Cell Mol Neurobiol 2008; 28: 833-845.
  23. So K, Moriya T, Nishitani S, Takahashi H, Shinohara K: The olfactory conditioning in the early postnatal period stimulated neuronal stem/progenitor cells in the subventricular zone and increased neurogenesis in the olfactory bulb of rats. Neuroscience 2008; 151: 120-128.
  24. Shimazoe T, Morita M, Ogiwara S, Kojiya T, Goto J, Kamakura M, Moriya T, Shinohara K, Takiguchi S, Kono A, Miyasaka K, Funakoshi A, Ikeda M: Cholecystokinin-A receptors regulate photic input pathways to the circadian clock. FASEB Journal 2008; 22: 1479-1490.
  25. 19. Moriya T, Hiraishi K, Horie N, Mitome M, Shinohara K: Correlative association between circadian expression of mPer2 gene and the proliferation of the neural stem cells. Neuroscience 2007; 146: 494-498.
  26. Moriya T, Horie N, Mitome M, Shinohara K: Melatonin influences the proliferative and differentiative activity of neural stem cells. J Pineal Res 2007; 42: 411-418.
  27. Nishihara E, Moriya T and Shinohara K: Expression of steroid receptor coactivator-1 is elevated during neuronal differentiation of murine neural stem cells. Brain Res 2007; 1135: 22-30.
  28. Nakamura TJ, Moriya T, Inoue S, Shimazoe T, Watanabe S, Ebihara S and Shinohara K: Estrogen differentially regulates expression of Per1 and Per2 genes between central and peripheral clocks and between reproductive and nonreproductive tissues in female rats. J Neurosci Res 2005; 82: 622-630.
  29. Yokota S, Moriya T, Shibata S: Inhibitory action of 5-HT1A agonist MKC-242 on triazolam-induced phase advances in hamster circadian activity rhythms. J Pharmacol Sci 2005; 98: 103-106.
  30. Kudo T, Akiyama M, Kuriyama K, Sudo M, Moriya T, Shibata S: Night-time restricted feeding normalises clock genes and Pai-1 gene expression in the db/db mouse liver. Diabetologia 2004; 47: 1425-1436.
  31. Horie N, Moriya T, Mitome M, Kitagawa N, Nagata I and Shinohara K: Lowered glucose suppressed the proliferation and increased the differentiation of murine neural stem cells in vitro. FEBS Lett 2004; 571: 237-242.
  32. Nishitani S, Moriya T, Kondo Y, Sakuma Y and Shinohara K: Induction of Fos immunoreactivity in oxytocin neurons in the paraventricular nucleus after female odor exposure in male rats: effects of sexual experience. Cell Mol Neurobiol 2004; 24: 283-291.
  33. Sudo M, Sasahara K, Moriya T, Akiyama M, Hamada T and Shibata S: Constant light housing attenuates circadian rhythms of mPer2 mRNA AND mPER2 protein expression in the suprachiasmatic nucleus of mice. Neuroscience 2003; 121: 493-499.
  34. Moriya T, Ikeda M, Teshima K, Hara R, Kuriyama K, Yoshioka T, Allen CN, Shibata S: Facilitation of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor transmission in the suprachiasmatic nucleus by aniracetam enhances photic responses of the biological clock in rodents. J Neurochem 2003; 85: 978-987.
  35. Iijima M, Nikaido T, Akiyama M, Moriya T, Shibata S: Methamphetamine-induced, suprachiasmatic nucleus-independent circadian rhythms of activity and mPer gene expression in the striatum of the mouse. Eur J Neurosci 2002; 16: 921-929.
  36. Minami Y, Furuno K, Akiyama M, Moriya T, Shibata S: Pituitary adenylate cyclase-activating polypeptide produces a phase shift associated with induction of mPer expression in the mouse suprachiasmatic nucleus. Neuroscience 2002; 113: 37-45.
  37. Takahashi S, Yoshinobu Y, Aida R, Shimomura H, Akiyama M, Moriya T, Shibata S: Extended action of MKC-242, a selective 5-HT(1A) receptor agonist, on light-induced Per gene expression in the suprachiasmatic nucleus in mice. J Neurosci Res 2002; 68: 470-478.
  38. Aida R, Moriya T, Araki M, Akiyama M, Wada K, Wada E, Shibata S: Gastrin-releasing peptide mediates photic entrainable signals to dorsal subsets of suprachiasmatic nucleus via induction of Period gene in mice. Mol Pharmacol 2002; 61: 26-34.
  39. Moriya T, Furukawa K, Nakamura H, Murai A and Ohizumi Y: The vaso-contractile action of zooxanthellatoxin-B from a marine dinoflagellate is mediated via Ca2+ influx in the rabbit aorta. Can J Physiol Pharmacol 2001; 79: 1030-1035.
  40. Asai M, Yoshinobu Y, Kaneko S, Mori A, Nikaido T, Moriya T, Akiyama M, Shibata S: Circadian profile of Per gene mRNA expression in the suprachiasmatic nucleus, paraventricular nucleus, and pineal body of aged rats. J Neurosci Res 2001; 66: 1133-1139.
  41. Takahashi S, Yokota S, Hara R, Kobayashi T, Akiyama M, Moriya T, Shibata S: Physical and inflammatory stressors elevate circadian clock gene mPer1 mRNA levels in the paraventricular nucleus of the mouse. Endocrinology 2001; 142: 4910-4917.
  42. Asai M, Yamaguchi S, Isejima H, Jonouchi M, Moriya T, Shibata S, Kobayashi M, Okamura H: Visualization of mPer1 transcription in vitro: NMDA induces a rapid phase shift of mPer1 gene in cultured SCN. Curr Biol 2001; 11: 1524-1527.
  43. Akiyama M, Minami Y, Nakajima T, Moriya T, Shibata S: Calcium and pituitary adenylate cyclase-activating polypeptide induced expression of circadian clock gene mPer1 in the mouse cerebellar granule cell culture. J Neurochem 2001; 78: 499-508.
  44. Yokota S, Yamamoto M, Moriya T, Akiyama M, Fukunaga K, Miyamoto E, Shibata S: Involvement of calcium-calmodulin protein kinase but not mitogen-activated protein kinase in light-induced phase delays and Per gene expression in the suprachiasmatic nucleus of the hamster. J Neurochem 2001; 77: 618-627.
  45. Nikaido T, Akiyama M, Moriya T, Shibata S: Sensitized increase of period gene expression in the mouse caudate/putamen caused by repeated injection of methamphetamine. Mol Pharmacol 2001; 59: 894-900.
  46. Wakamatsu H, Yoshinobu Y, Aida R, Moriya T, Akiyama M, Shibata S: Restricted-feeding-induced anticipatory activity rhythm is associated with a phase-shift of the expression of mPer1 and mPer2 mRNA in the cerebral cortex and hippocampus but not in the suprachiasmatic nucleus of mice. Eur J Neurosci 2001; 13: 1190-1196.
  47. Hara R, Wan K, Wakamatsu H, Aida R, Moriya T, Akiyama M, Shibata S: Restricted feeding entrains liver clock without participation of the suprachiasmatic nucleus. Genes to Cells 2001; 6: 269-278.
  48. Yamamoto S, Shigeyoshi Y, Ishida Y, Fukuyama T, Yamaguchi S, Yagita K, Moriya T, Shibata S, Takashima N and Okamura H: Expression of the Per1 gene in the hamster: brain atlas and circadian characteristics in the suprachiasmatic nucleus. J Comp Neurol 2001; 430: 518-532.
  49. Shimomura H, Moriya T, Sudo M, Wakamatsu H, Akiyama M, Miyake Y, Shibata S: Differential daily expression of Per1 and Per2 mRNA in the suprachiasmatic nucleus of fetal and early postnatal mice. Eur J Neurosci 2001; 13: 687-693. (IF=2.975)
  50. Wakamatsu H, Takahashi S, Moriya T, Inouye ST, Okamura H, Akiyama M, Shibata S: Additive effect of mPer1 and mPer2 antisense oligonucleotides on light-induced phase shift. Neuroreport 2001; 12: 127-131.
  51. Yokota SI, Horikawa K, Akiyama M, Moriya T, Ebihara S, Komuro G, Ohta T, Shibata S: Inhibitory action of brotizolam on circadian and light-induced per1 and per2 expression in the hamster suprachiasmatic nucleus. Br J Pharmacol 2000; 131: 1739-1747.
  52. Moriya T, Horikawa K, Akiyama M, Shibata S: Correlative association between N-methyl-D-aspartate receptor-mediated expression of period genes in the suprachiasmatic nucleus and phase shifts in behavior with photic entrainment of clock in hamsters. Mol Pharmacol 2000; 58: 1554-1562.
  53. Moriya T, Kouzu Y, Shibata S, Kadotani H, Fukunaga K, Miyamoto E, Yoshioka T: Close linkage between calcium/calmodulin kinase II alpha/beta and NMDA-2A receptors in the lateral amygdala and significance for retrieval of auditory fear conditioning. Eur J Neurosci 2000; 12: 3307-3314.
  54. Moriya T, Takahashi S, Ikeda M, Suzuki-Yamashita K, Asai M, Kadotani H, Okamura H, Yoshioka T, Shibata S: N-methyl-D-aspartate receptor subtype 2C is not involved in circadian oscillation or photoic entrainment of the biological clock in mice. J Neurosci Res 2000; 61: 663-673.
  55. Horikawa K, Yokota S, Fuji K, Akiyama M, Moriya T, Okamura H, Shibata S: Nonphotic entrainment by 5-HT1A/7 receptor agonists accompanied by reduced Per1 and Per2 mRNA levels in the suprachiasmatic nuclei. J Neurosci 2000; 20: 5867-5873.
  56. Stork O, Ji FY, Kaneko K, Stork S, Yoshinobu Y, Moriya T, Shibata S, Obata K: Postnatal development of a GABA deficit and disturbance of neural functions in mice lacking GAD65. Brain Res 2000; 865: 45-58.
  57. Moriya T, Yoshinobu Y, Kouzu Y, Katoh A, Gomi H, Ikeda M, Yoshioka T, Itohara S, Shibata S: Involvement of glial fibrillary acidic protein (GFAP) expressed in astroglial cells in circadian rhythm under constant lighting conditions in mice. J Neurosci Res 2000; 60: 212-218.
  58. Ikeda M, Sugiyama T, Suzuki K, Moriya T, Shibata S, Katsuki M, Allen CN, Yoshioka T: PLC beta 4-independent Ca2+ rise via muscarinic receptors in the mouse suprachiasmatic nucleus. Neuroreport 2000; 11: 907-912.
  59. Kouzu Y, Moriya T, Takeshima H, Yoshioka T, Shibata S: Mutant mice lacking ryanodine receptor type 3 exhibit deficits of contextual fear conditioning and activation of calcium/calmodulin-dependent protein kinase II in the hippocampus. Mol Brain Res 2000; 76: 142-150.
  60. Wan K, Moriya T, Akiyama M, Takeshima H, Shibata S: Involvement of ryanodine receptor type 3 in dopamine release from the striatum: evidence from mutant mice lacking this receptor. Biochemical and Biophysical Research Communications 1999; 266: 588-592.
  61. Akiyama M, Kirihara T, Takahashi S, Minami Y, Yoshinobu Y, Moriya T, Shibata S: Modulation of mPer1 gene expression by anxiolytic drugs in mouse cerebellum. Br J Pharmacol 1999; 128: 1616-1622.
  62. Nikaido T, Moriya T, Takabayashi R, Akigama M, Shibata S: Sensitization of methamphetamine-induced disorganization of daily locomotor activity rhythm in male rats. Brain Res 1999; 845: 112-116.
  63. Akiyama M, Kouzu Y, Takahashi S, Wakamatsu H, Moriya T, Maetani M, Watanabe S, Tei H, Sakaki Y, Shibata S: Inhibition of light- or glutamate-induced mPer1 expression represses the phase shifts into the mouse circadian locomotor and suprachiasmatic firing rhythms. J Neurosci 1999; 19: 1115-1121.
  64. Moriya T, Yoshinobu Y, Ikeda M, Yokota S, Akiyama M, Shibata S: Potentiating action of MKC-242, a selective 5-HT1A receptor agonist, on the photic entrainment of the circadian activity rhythm in hamsters. Br J Pharmacol 1998; 125: 1281-1287.
  65. Ikeda M, Asai M, Moriya T, Sagara M, Inoue S, Shibata S: Methylcobalamin amplifies melatonin-induced circadian phase shifts by facilitation of melatonin synthesis in the rat pineal gland. Brain Res 1998; 795: 98-104.
  66. Moriya T, Ishida Y, Nakamura H, Asari T, Murai A, Ohizumi Y: Vasoconstriction induced by zooxanthellatoxin-B, a polyoxygenated long-chain product from a marine alga. Eur J Pharmacol 1998; 350: 59-65.
  67. Shigeyoshi Y, Taguchi K, Yamamoto S, Takekida S, Yan L, Tei H, Moriya T, Shibata S, Loros JJ, Dunlap JC, Okamura H: Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript. Cell 1997; 91: 1043-1053.
  68. Yamanouchi S, Shimazoe T, Nagata S, Moriya T, Maetani M, Shibata S, Watanabe S, Miyasaka K, Kono A, Funakoshi A: Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats. Neurosci Lett 1997; 227: 103-106.
  69. Watanabe A, Moriya T, Nisikawa Y, Araki T, Hamada T, Shibata S, Watanabe S: Adenosine A1-receptor agonist attenuates the light-induced phase shifts and fos expression in vivo and optic nerve stimulation-evoked field potentials in the suprachiasmatic nucleus in vitro. Brain Res 1996; 740: 329-336.
  70. Moriya T, Yamanouchi S, Fukushima T, Shimazoe T, Shibata S, Watanabe S: Involvement of 5-HT1A receptor mechanisms in the inhibitory effects of methamphetamine on photic responses in the rodent suprachiasmatic nucleus. Brain Res 1996; 740: 261-267.
  71. Ono M, Watanabe A, Matsumoto Y, Fukushima T, Nishikawa Y, Moriya T, Shibata S, Watanabe S: Methamphetamine modifies the photic entraining responses in the rodent suprachiasmatic nucleus via serotonin release. Neuroscience 1996; 72: 213-224.
  72. Moriya T, Fukushima T, Shimazoe T, Shibata S, Watanabe S: Chronic administration of methamphetamine does not affect the suprachiasmatic nucleus-operated circadian pacemaker in rats. Neurosci Lett 1996; 208: 129-132.
  73. Oshima Y, Yamada S, Matsunaga K, Moriya T, Ohizumi Y: A monogalactosyl diacylglycerol from a cultured marine dinoflagellate, Scrippsiella trochoidea. J Nat Prod 1994; 57: 534-536.

所属学会・団体名
  • 日本薬学会
  • 日本薬理学会
  • 日本時間生物学会
  • 日本ラクトフェリン学会
  • 日本神経科学学会
  • 日本睡眠学会
  • 日本生気象学会
  • 日本毒性学会
  • 日本医療薬学会


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