化学Ⅰ/化学Ⅱ/有機化学Ⅰ/有機化学Ⅲ/薬学演習Ⅰ・Ⅱ・Ⅳ・Ⅴ・Ⅵ/薬学基礎実習/化学系実習/卒業研究

研究テーマ

1. 互変異性ピリミジン系複素環化合物の効率的合成法の開発

2. ピリミジン系複素環化合物の機能開発と生物活性

3. 新しい触媒的ラジカル反応の開発

論文など

1. Kubo, T.; Yanagihara, K.; Nishimura, Y.; Iino, Y.; Komatsu, T.; Tansou, R.; Mihara, K.; Seyama, T. Antitumor Effect of Oleoyl-siRNA against Pancreatic Cancer Using a Portal Vein Infusion Liver-Metastatic Mouse Model. Molecular Pharmaceutics  2024, 21, 5115–5125.

2. Nishimura, Y.; Kubo, T.; Shibuya, N.; Cho, H. Fully Substituted Dihydropyrimidines, Pentasubstituted 2-Aryldihydropyrimidines Synthesized by Palladium-catalyzed/copper-mediated Cross-coupling Reaction. Synthesis  2023, 55, 1996–2004.

3. Nishimura, Y.; Kubo, T.; Takayama, S.; Yoshida, H.; Cho, H. Palladium-catalyzed/copper-mediated carbon-carbon cross-coupling reaction for synthesis of 6-unsubstituted 2-aryldihydropyrimidines. RSC Advances  2022, 12, 28113–28122.

4. Nishimura, Y.; Kikuchi, H.; Kubo, T.; Arai, R.; Toguchi, Y.; Yuan, B.; Sunaga, K.; Cho, H. Synthesis of 4,4-Disubstituted 3,4-Dihydropyrimidin-2(1H)-ones and -thiones, the Corresponding Products of Biginelli Reaction Using Ketone, and Their Antiproliferative Effect on HL-60 Cells. Chem. Pharm. Bull.  2022, 70, 111–119.

5. Nishimura, Y.; Kikuchi, H.; Kubo, T.; Nakakita, I.; Oguni, M.; Ohta, M.; Arai, R.; Yuan, B.; Sunaga, K.; Cho, H. Synthesis of novel 6-unsubstituted 2-aminodihydropyrimidines by Sc(OTf)3-mediated amination and their antiproliferative effect on HL-60 cells. Tetrahedron Lett.  2021, 65, 152760.

6. Nishimura, Y. Development of efficient synthetic method for tautomeric dihydropyrimidines and analysis of their functionality. YAKUGAKU ZASSHI  2021, 141, 151–161.

7. Kubo, T.; Nishimura, Y.; Sato, Y.; Yanagihara, K.; Seyama, T. Sixteen diffrent types of lipid-conjugated siRNAs containing saturated and unsaturated fatty acids and exhibiting enhanced RNAi potency. ACS Chemical Biology  2021, 16, 150–164.

8. Nishimura, Y.; Kikuchi, H.; Kubo, T.; Gokurakuji, Y.; Nakamura, Y.; Arai, R.; Yuan, B.; Sunaga, K.; Cho, H. Synthesis of 6-unsubstituted 2-oxo, 2-thioxo, 2-amino-3,4-dihydropyrimidines and their antiproliferative effect on HL-60 cells. Tetrahedron Lett.  2020, 61, 151967.

9. Kubo, T.; Nishimura, Y.; Hatori, Y.; Akagi, R.; Mihara, K.; Yanagihara, K.; Seyama, T. Antitumor effect of palmitic acid-conjugated DsiRNAs for colon cancer in a mouse subcutaneous tumor model. Chemical Biology & Drug Design  2019, 93, 570–581.

10. Cho, H.; Nishimura, Y.; Ikeda, H.; Asakura, M.; Toyota, S. Experimental and theoretical studies on thermodynamics and properties of tautomers of 2-substituted 6(4)-methyl-1,4(1,6)-dihydropyrimidine-5-carboxylates. Tetrahedron  2018, 74, 2405–2413.

11. Nishimura, Y.; Kubo, T.; Okamoto, Y.; Cho, H. Convergent synthesis of 4,6-unsubstituted 5-acyl-2-aminodihydropyrimidines using Weinreb amide group. Tetrahedron Lett.  2017, 58, 4236–4239.

12. Nishimura, Y.; Kubo, T.; Okamoto, Y.; Cho, H. Convergent synthesis of 4,6-unsubstituted 5-acyl-2-phenyldihydropyrimidines by substitution reactions of Weinreb amide group of tetrahydropyrimidine. Tetrahedron Lett.  2016, 57, 4492–4495.

13. Nishimura, Y.; Cho, H. Synthesis of 4,6-Unsubstituted 2-Aminodihydropyrimidine-5-carboxylates through Sequential Staudinger/Aza-Wittig/Cyclization Reactions. Synlett  2015, 26, 233–237.

14. Nishimura, M.; Nishimura, Y.; Abe, C.; Kohhata, M. Expression of Substrate Range of Streptomyces Vanillate Demethylase. Biol. Pharm. Bull.  2014, 37, 1564–1568.

15. Nishimura, Y.; Cho, H. Synthesis of 4-unsubstituted dihydropyrimidines having acyl and alkoxycarbony groups at 5- and 6-positions by cyclization-elimination reactions using 1,3-diaza-1,3-butadienes. Tetrahedron Lett.  2014, 55, 411–414.

16. Nishi, H.; Ikunaka, M.; Nishimura, Y. Development of the Novel Stereoselective Synthetic Process for an Optically Active Intermediate of (-)-Ranirestat: Aldose Reductase Inhibitor and its Optical Purity Testing Method by HPLC. 安田女子大学紀要  2014, 42, 337–345.

17. Kubo, T.; Yanagihara, K.; Sato, Y.; Nishimura, Y.; Kondo, S.; Seyama, T. Gene-silencing potency of symmetric and asymmetric lipid-conjugated siRNAs and its correlation with Dicer recognition. Bioconjugate Chemistry  2013, 24, 2045–2057.

18. Kikuchi, H.; Yuan, B.; Nishimura, Y.; Imai, M.; Furutani, R.; Kamoi, S.; Seno, M.; Fukushima, S.; Hazama, S.; Hirobe, C.; Ohyama, K.; Hu, X.-M.; Takagi, N.; Hirano, T.; Toyoda, H. Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines. International Journal of Oncology  2013, 43, 1976–1984.

19. Nishimura, Y.; Yasui, Y.; Kobayashi, S.; Yamaguchi, M.; Cho, H. Synthesis of novel 2-phenyl-5-substituted dihydropyrimidines using 2-phenyl-1,3-diaza-1,3-butadienes and electron-deficient olefins. Tetrahedron  2012, 68, 3342–3350.

20. Cho, H.; Nishimura, Y.; Yasui, Y.; Yamaguchi, M. Construction of dihydropyrimidine skeleton using 1,2,4-trisubstituted-1,3-diaza-1,3-butadienes. Tetrahedron Lett.  2012, 53, 1177–1179.

21. Cho, H.; Kwon, E.; Yasui, S.; Kobayashi, S.; Nishimura, Y.; Yamaguchi, M. Ring cleavage of dihydropyrimidine skeleton. Tetrahedron Lett.  2011, 52, 7185–7188.

22. Nishimura, Y.; Okamoto, Y.; Ikunaka, M.; Ohyama, Y. Synthetic Studies on Novel 1,4-Dihydro-2-methylthio-4,4,6-trisubstituted Pyrimidine-5-carboxylic Acid Esters and Their Tautomers. Chem. Pharm. Bull.  2011, 59, 1458–1466.

23. Nishimura, M.; Kohno, K.; Nishimura, Y.; Inagaki, M.; Davies, J. Characterization of Two Isozymes of Coniferyl Alcohol Dehydrogenase from Streptomyces sp. NL15-2K. Bioscience, Biotechnology, and Biochemistry  2011, 75, 1770–1777.

24. Cho, H.; Nishimura, Y.; Yasui, Y.; Kobayashi, S.; Yoshida, S.; Kwon, E.; Yamaguchi, M. Synthesis of 4-unsubstituted dihydropyrimidines. Nucleophilic substitution at position-2 of dihydropyrimidines. Tetrahedron  2011, 67, 2661–2669.

25. Nishimura, Y.; Kiryu, M.; Suwa, K.; Amemiya, R.; Yamaguchi, M. Gallium Trichloride-Promoted Ethynylation Reaction of 1,4-Dienes. Adv. Synth. Catal.  2008, 350, 1271–1274.

26. Nishimura, Y.; Shiraishi, T.; Yamaguchi, M. (Z)-selective Wittig and Corey-Chaykovsky Reactions of Propargyl Ylides Using Trialkylgallium Bases. Tetrahedron Lett.  2008, 49, 3492–3495.

27. Yamaguchi, M.; Nishimura, Y. Trichlorogallium and Trialkylgalliums in Oganic Synthesis. Chem. Commun.  2008, 35–48.

28. Nishimura, Y.; Miyake, Y.; Amemiya, R.; Yamaguchi, M. Triethylgallium as a Nonnucleophilic Base to Generate Enolates from Ketones. Org. Lett.  2006, 8, 5077–5080.

29. Nishimura, Y.; Amemiya, R.; Yamaguchi, M. α-Ethynylation Reaction of Ketones Using Catalytic Amounts of Trialkylgallium Base. Tetrahedron Lett.  2006, 47, 1839–1843.

30. Amemiya, R.; Suwa, K.; Toriyama, J.; Nishimura, Y.; Yamaguchi, M. One-Step Synthesis of Triethynylvinylmethanes and Tetraethynylmethanes by GaCl3-Promoted Diethynylation of 1,4-Enynes and 1,4-Dienes. J. Am. Chem. Soc.  2005, 127, 8252–8253.

31. Amemiya, R.; Nishimura, Y.; Yamaguchi, M. GaCl3-Catalyzed α-Ethenylation Reaction of Ketone. Synthesis  2004, 1307–1314.

日本薬学会

日本化学会

有機合成化学協会

日本プロセス化学会

受賞歴など

2019年度　日本薬学会中国四国支部奨励賞

2005年度　日本学術振興会特別研究員奨励費(DC2)