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教員紹介

小野　哲也 准教授 [Tetsuya Ono]

担当授業科目
物理化学Ⅰ・Ⅱ・Ⅳ/薬学演習Ⅰ・Ⅱ・Ⅳ・Ⅵ/薬学基礎実習/物理系実習/薬剤学実習/卒業研究
主な研究
主な研究テーマ
  1. 有機触媒を利用した新規電気化学分析法の構築と応用
  2. 機能性薄膜を用いた薬物放出制御システムの構築

研究
研究論文
  1. K. Sugiyama, F. Sato, K. Yoshida, S. Komatsu, T. Ono, Y. Sasano, Y. Iwabuchi, T. Fujimura, Y. Kashiwagi, K. Sato, Colorimetric quantification of vancomycin by highly active nitroxyl radical compounds, Anal. Sci. 2025, 41, 179-183; doi: 10.1007/s44211-024-00686-5
  2. T. Dairaku,* K. Nozawa-Kumada, T. Ono, K. Yoshida, Y. Kashiwagi, Y. Tanaka, J. Kondo, M. Tanabe, DNA Duplex Containing Ag+-Mediated cytosine-cytosine base pairs as a Catalyst Precursor for the 4-Nitrophenol Reduction with NaBH4,  Inorg. Chem. 2024, 63, 22845-22855; doi: 10.1021/acs.inorgchem.4c03830
  3. T. Ono,* F. Sato, M. Kumano, S. Komatsu, K. Sugiyama, K. Watanabe, K. Yoshida, Y. Sasano, T. Fujimura, Y. Iwabuchi, Y Kashiwagi, K. Sato,*  Determination of antibiotics by amperometry using nortropine N-oxyl, a highly active nitroxyl radical,  Anal. Sci. 2023, 39, 1771-1775; doi: 10.1007/s44211-023-00388-4
  4. M. Toda, Y. Sasano, M. Takahashi, S. Fujiki, K. Kasabata, T. Ono, K. Sato, Y Kashiwagi, Y. Iwabuchi,* Identification of the Optimal Framework for Nitroxyl Radical/Hydroxylamine in Copper-Cocatalyzed Aerobic Alcohol Oxidation, J. Org. Chem. 2023, 88(3), 1434-1444; doi: 10.1021/acs.joc.2c02327
  5. M. Kumano, K. Sugiyama, F. Sato, S. Komatsu, K. Watanabe, T. Ono, K. Yoshida, Y. Sasano, Y. Iwabuchi, T. Fujimura, Y. Kashiwagi,* K. Sato, Electrochemical reactions of highly active nitroxyl radicals with thiol compounds, Anal. Sci. 2023, 39, 369-374; doi: 10.1007/s44211-00246-9
  6. K. Yoshida,* T. Kamijo, T. Ono, T. Dairaku, S. Takahashi, Y. Kashiwagi, K. Sato, Electrical stimuli-responsive decomposition of layer-by-layer films composed of polycations and TEMPO-modified poly(acrylic acid), Polymers 2022, 14, 5349; doi: 10.3390/polym14245349
  7. 佐藤勝彦, 熊野征行, 杉山恭子, 小松祥子, 渡邉一弘, 今橋良太, 小野哲也, 吉田健太郎, 大樂武範, 藤村務, 柏木良友, フェノール側鎖を有するニトロキシルラジカル前駆体の水溶液中での電気化学的重合とその電気化学分析への応用, Bunseki Kagaku 2022, 71(3), 191-196; doi: 10.2116/bunsekikagaku.71.191
  8. K. Sugiyama, Y. Sasano,* S. Komatsu, K. Yoshida, T. ono, T. Fujimura, Y. Iwabuchi, Y. Kashiwagi, K. Sato,* Nitroxyl Radical/Copper-Catalyzed Electrooxidation of Alcohols and Amines at Low Potentials, Chem. Pharm. Bull. 2021, 69, 1005-1009; doi: 10.1248/cpb.c21-00409
  9. T. Dairaku,* R. Kawai, K. Nozawa-Kumada, K. Yoshida, T. Ono, Y. Kondo, J. Kondo, A. Ono, Y. Tanaka, Y. Kashiwagi,* Chemical reduction of Ag+ to Ag employing organic electron donors: evaluation of the effect of Ag+-mediated cytosine-cytosine base pairing on the aggregation of Ag nanoparticles,  Dalton Trans. 2021, 50, 12208-12214; doi: 10.1039/d1dt01927a
  10. T. Ono,* K. Sugiyama, S. Komatsu, M. Kumano, K. Yoshida, T. Dairaku, T. Fujimura, Y. Sasano, Y. Iwabuchi, Y. Kashiwagi, K. Sato,* Catalysis of electro-oxidation of antibiotics by nitroxyl radicals and the electrochemical sensing of vancomycin, RSC Adv. 2021, 11, 21622-21628; doi: 10.1039/d1ra03681e
  11. T. Dairaku,* R. Kawai, T. Kanaba, T. Ono, K. Yoshida, H. Sato, K. Nozawa-Kumada, Y. Kondo, J. Kondo, A. Ono, Y. Tanaka,* Y. Kashiwagi,* Effect of cytosine-Ag+-cytosine base pairing on the redox potential of the Ag+/Ag couple and thr chemical reduction of Ag+ to Ag by tetrathiafulvalene, Dalton Trans. 2021, 50, 7633-7639; doi: 10.1039/d1dt00975c.
  12. S. Komatsu, Y. Sasano, K. Sugiyama, K. Watanabe, M. Kumano, K. Yoshida, T. Ono, Y. Iwabuchi, T. Fujimura, K. Sato,* Y. Kashiwagi,* Electrochemical Evaluation of Nitroxyl Radical Catalysts and Electrochemical Detection of Cyclosporin A, Int. J. Electrochem. Sci. 2021, 16, 21027; doi: 10.20964/2021.02.30
  13. K. Sugiyama, K. Watanabe, S. Komatsu, K. Yoshida, T. Ono, T. Fujimura, Y. Kashiwagi, K. Sato, Electropolymerization of Azure A and pH sensing using poly(Azure A)-modified electrodes, Anal. Sci. 2021, 37, 893-896; doi: 10.2116/analsci.20P341
  14. K. Watanabe,* K. Sugiyama, K. Yoshida, T. Ono, T. Fujimura, Y. Kashiwagi, K. Sato,* Voltammetric pH measurements Using Azure A-Containing Layer-by-Layer Film Immobilized Electrodes, Polymers 2020, 12, 2328; doi: 10.3390/polym12102328
  15. K. Yoshida,* A. Yamaguchi, H. Midorikawa, T. Kamijo, T. Ono, T. Dairaku, T. Sato, T. Fujimura, Y. Kashiwagi, K. Sato, Adsorption and Release of Rose Bengal on Layer-by-Layer Films of Poly(Vinyl Alcohol) and Poly(Amidoamine) Dendrimers Bearing 4-Carboxyphenylboronic Acid, Polymers 2020, 12, 1854; doi: 10.3390/polym12081854
  16. K. Yoshida,* Y. Kashimura, T. Kamijo, T. Ono, T. Dairaku, T. Sato, Y. Kashiwagi, K. Sato, Decomposition of Glucose-Sensitive Layer-by-Layer Films Using Hemin, DNA, and Glucose Oxidase, Polymers 2020, 12, 319; doi: 10.3390/polym12020319
  17. Y. Kashiwagi,* T. Ono, F. Sato, M. Kumano, K. Yoshida, T. Dairaku, Y. Sasano, Y. Iwabuchi, K. Sato, Electrochemical determination of choline using nortropine-N-oxyl for a nonenzymatic system, Sens. Bio-Sensing Res. 2020, 27, 100302; doi: 10.1016/j.sbsr.2019.100302
  18. T. Ono,* K. Sato, Y. Sasano, K. Yoshida, T. Dairaku, Y. Iwabuchi Y. Kashiwagi, Electrochemical Determination of Triglycerides Based on an Enzymatic Reaction and Electrocatalytic Oxidation with Nortropine-N-Oxyl, Electroanalysis 2019, 31, 603-606; doi: 10.1002/elan.201800660
  19. K. Sato, T. Ono, Y. Sasano, F. Sato, M. Kumano, K. Yoshida, T. Dairaku, Y. Iwabuchi, Y. Kashiwagi, Electrochemical Oxidation of Amines Using a Nitroxyl Radical Catalyst and the Electroanalysis of Lidocaine, Catalysts 2018, 8, 649; doi: 10.3390/catal8120649
  20. K. Yoshida, T. Ono, T. Dairaku, Y. Kashiwagi, K. Sato, Preparation of Hydrogen Peroxide Sensitive Nanofilms by a Layer-by-Layer Technique, Nanomaterials 2018, 8, 941; doi: 10.3390/nano8110941
  21. K. Yoshida, K Awaji, S. Shimizu, M. Iwasaki, Y. Oide, M. Ito, T. Dairaku, T. Ono, Y. Kashiwagi, K. Sato, Preparation of Microparticles Capable of Glucose-Induced Insulin Release under Physiological Conditions, Polymers 2018, 10, 1164; doi: 10.3390/polym10101164
  22. K. Yoshida, K. Sato, T. Ono, T. Dairaku, Y. Kashiwagi, Preparation of Nafion/Polycation Layer-by-Layer Films for Adsorption and Release of Insulin, Polymers 2018, 10, 812; doi: 10.3390/polym10080812
  23. Y. Kashiwagi, T. Ono, K. Yoshida, T. Ito, N. Sakurai, Construction of PQQ-Enzyme Multi-Immobilized Electrodes for Electrocatalytic Reduction of Carbonyl Compounds, Heterocycles 2018, 7, 1216-1225; doi: 10.3987/COM-18-13920
  24. T. Ono, K. Sato, S. Shimizu, K. Yoshida, T. Dairaku, Y. Suzuki, Y. Kashiwagi, Electrocatalytic Oxidation of Carbohydrates Mediated by Nitroxyl Radical-Modified Electrodes in Aqueous Solution, Electroanalysis 2018, 30, 24-26; doi: 10.1002/elan.201700545
  25. K. Yoshida, T. Ono, Y. Kashiwagi, S. Takahashi, K. Sato, J. Anzai, Polymers 2015, 7, 1269-1278; doi: 10.3390/polym7071269
  26. K. Sato, T. Ono, K. Yoshida, T. Ito, Y. Kashiwagi, Electroanalysis 2015, 27, 2272-2274; doi: 10.1002/elan.201500059
総説等
  1. T. Ono,* Electrochemical analysis using organic nitroxyl radicals, Yakugaku Zasshi 2023, 143, 95-100; doi: 10.1248/yakushi.22-00143
  2. 小野哲也,* 有機ニトロキシルラジカルを利用した電気化学分析, bunseki 2021, 8, 389-390; doi: 10.1007/s44211-00246-9

所属学会・団体名
  • 日本薬学会
  • 日本分析化学会



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