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教員紹介

関 健二郎 准教授 [Kenjiro Seki]

担当授業科目
  • 薬と病態(生体内で生み出される生理活性物質)
  • 薬と病態(精神疾患)
  • 薬と病態(神経・筋疾患)
  • 薬と病態チュートリアル(神経疾患)
  • 医薬品毒性学
  • 新薬概論
  • 薬理学実習
  • 特別実習

主な研究
主な研究テーマ
  1. 脳神経回路における興奮性-抑制性神経の役割
  2. シナプス可塑性と精神疾患
  3. うつ病発症の神経機構
  4. 衝動的攻撃性の神経機構
  5. せん妄モデルマウスの作成と治療法の開発研究

最近の主な研究論文
  1. Sayori Yashiro and Kenjiro Seki * Association of social defeat stress-induced anhedonia-like symptoms with mGluR1-dependent downregulation of membrane AMPA-GluR1 in the mouse ventral midbrain. Stress, 2017, in press *Corresponding author.
  2. Koh Shimizu, Natsuki Kurosawa, Kenjiro Seki * Chronic social isolation induced down-regulation of serotonin 5-HT3 receptor in hypothalamus is associated with the acceleration of aggressive behavior in mice. Physiol Behav., 2016, Jan: 153, p.70-83. *Corresponding author
  3. Natsuki Kurosawa, Koh Shimizu, Kenjiro Seki * The development of depression-like behavior is consolidated by IL-6-induced activation of locus coeruleus neurons and IL-1β-induced elevated leptin levels in mice, Psychopharmacology (Berl); 233(9): p.1725-37., *Corresponding author.
  4. 佐藤 佳澄、八代 彩愛、関 健二郎 * 長期隔離飼育マウスの攻撃性獲得と抑うつ症状発症に対するオイゲノール芳香の予防効果, Aroma Research 11月号(vol.16/No.4)2015, p.368-375, *Corresponding author. 2015年度・論文奨励賞受賞
  5. Nobuaki Ohtake, Mieko Saito, Masaaki Eto,Kenjiro Seki * Exendin-4 promotes the membrane trafficking of the AMPA receptor GluR1 subunit and ADAM10 in the mouse neocortex., World Biomedical Frontiers, PMID: 24769307, May 2015, *Corresponding author.
  6. Ryo Ohshima, Kanae Hotsumi, Christian Holscher, Kenjiro Seki * Age-related decrease in glucagon-like peptide-1 in mouse prefrontal cortex but not in hippocampus despite the preservation of its receptor, American J. BioSci., Vol. 3, No. 1, p. 11-27., 2015, *Corresponding author.
  7. Miyu Sekio and Kenjiro Seki * Lipopolysaccharide-induced depressive-like behavior is associated with α1-adrenoceptor dependent downregulation of the membrane GluR1 subunit in the mouse medial prefrontal cortex and ventral tegmental area., Int J Neuropsychopharmacol (2015) 18 (1), p.1-12: 31 October 2014, *Corresponding author.
  8. Nobuaki Ohtake, Mieko Saito, Masaaki Eto, Kenjiro Seki * Exendin-4 promotes the membrane trafficking of the AMPA receptor GluR1 subunit and ADAM10 in the mouse neocortex., Regul Pept. 2014 Apr 24; 190-191C: p.1-11., *Corresponding author.

所属学会・団体名
  • 日本薬学会
  • 日本薬理学会
  • 日本栄養・食糧学会

E-mail

k-seki@pha.ohu-u.ac.jp