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教員紹介

野島 浩史 教授 [Hiroshi Nojima]

担当授業科目
  • 機能形態学Ⅰ・Ⅱ
  • 生物系実習工
  • 特別実習

研究
研究テーマ
  1. かゆみの発生と調節機構
  2. 鎮痒作用物質の探索
  3. かゆみマウスモデルの新規作製

研究論文
  1. Abe M, Munakata H, Abe K, Saito T, Horiguchi Y, Nojima H, Taguchi K.: Effects of 1-cyclohexyl- and 1-cyclohexyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline on dopaminergic spontaneous discharge in nigral neurons of rats. Brain Res. Bull. (in press)
  2. Chiba H, Sato H, Abe K, Saito T, Horiguchi Y, Nojima H, Taguchi K.: Effects of 1,2,3,4-tetrahydroisoquinoline derivatives on dopaminergic spontaneous discharge in substantia nigra neurons in rats. Pharmacology 95 (1-2), 87-94 (2015)
  3. Abe K, Kobayashi K, Yoshino S, Taguchi K, Nojima H.: Withdrawal of repeated morphine enhances histamine-induced scratching responses in mice. Drug Chem Toxicol. 38 (2), 167-173 (2015)
  4. Saitoh K, Abe K, Chiba T, Katagiri N, Saitoh T, Horiguchi Y, Nojima H, Taguchi K.: Properties of 3-methyl-TIQ and 3-methyl-N-propargyl-TIQ for preventing MPTP-induced parkinsonism-like symptoms in mice. Pharmacol Rep. 65 (5), 1204-1212 (2013)
  5. Takasaki I, Taniguchi K, Komatsu F, Sasaki A, Andoh T, Nojima H, Shiraki K, Hsu DK, Liu FT, Kato I, Hiraga K, Kuraishi Y.: Contribution of spinal galectin-3 to acute herpetic allodynia in mice. Pain. 153 (3), 585-592 (2012)
  6. Abe K, Fujii Y, Nojima H.: Evaluation of hyperalgesia in spared nerve injury model using mechanical, thermal, and chemical stimuli in the mouse. Neurol Res. 33 (6), 656-662 (2011)
  7. Katagiri N, Chida S, Abe K, Nojima H, Kitabatake M, Hoshi K, Horiguchi Y, Taguchi K.: Preventative effects of 1,3-dimethyl- and 1,3-dimethyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline on MPTP-induced Parkinson's disease-like symptoms in mice. Brain Res. 1321, 133-142 (2010)
  8. Nishikawa Y, Sasaki A, Andoh T, Nojima H, Shiraki K, Kuraishi Y.: Modality-specific hyperexcitability of dorsal horn neurons to mechanical stimuli in herpetic mice. Neuroreport. 20 (12), 1077-1080 (2009)
  9. Omori Y, Kagaya K, Enomoto R, Sasaki A, Andoh T, Nojima H, Takahata H, Kuraishi Y.: A mouse model of sural nerve injury-induced neuropathy: gabapentin inhibits pain-related behaviors and the hyperactivity of wide-dynamic range neurons in the dorsal horn. J Pharmacol Sci. 109 (4), 532-539 (2009)
  10. Abe K, Sato R, Ohkoshi E, QI J-F, LI W, Fujii Y, Nojima H.,: Antipruritic effects of the supercritical fluid extract from Cnidii monnieri fructus (dried fruits of Cnidium monnieri Cusson) in mice. Pharmacometrics 75 (1/2), 33-38 (2008)
  11. Kuraishi Y, Yageta Y, Konno M, Andoh T, Yamaguchi-Miyamoto T, Nojima H.: Intracisternal, but not intrathecal, injection of naloxone inhibits cutaneous itch-related response in mice. Biol Pharm Bull. 31 (11), 2143-2145 (2008)
  12. Nakano T, Andoh T, Sasaki A, Nojima H, Kuraishi Y.: Different roles of capsaicin-sensitive and H1 histamine receptor-expressing sensory neurones in itch of mosquito allergy in mice. Acta Derm Venereol. 88 (5), 449-54 (2008)
  13. Andoh T, Yageta Y, Konno M, Yamaguchi-Miyamoto T, Takahata H, Nojima H, Nemoto H, Kuraishi Y.: Evidence for separate involvement of different mu-opioid receptor subtypes in itch and analgesia induced by supraspinal action of opioids. J Pharmacol Sci. 106 (4), 667-670 (2008)
  14. Andoh T, Sugiyama K, Fujita M, Iida Y, Nojima H, Saiki I, Kuraishi Y.: Pharmacological evaluation of morphine and non-opioid analgesic adjuvants in a mouse model of skin cancer pain. Biol Pharm Bull. 31 (3), 520-522 (2008)

所属学会・団体名
  • 日本薬理学会
  • 日本薬学会

その他
著書
  1. 野島浩史:オピオイドとかゆみ.かゆみ最前線 62-65,宮地良樹,生駒晃彦編=皮膚科診療最前線シリーズ,メディカルレビュー社(2006)
  2. 野島浩史:アトピー性皮膚炎自然発症マウスを用いた皮膚掻痒症の発症機構の解明.ファルマシア 41(6), 539-542(2005)

E-mail

h-nojima@pha.ohu-u.ac.jp