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教員紹介

小谷 政晴 教授 [Masaharu Kotani]

担当授業科目
  • 生化学実習
  • 分子生物学
  • 総合薬学演習Ⅰ・Ⅱ
  • ゲノム創薬概論
  • 特別実習

主な研究
主な研究テーマ

神経幹細胞の分子細胞生物学的研究

  1. 神経幹細胞に特異的な膜表面抗原の探査と機能に関する研究
  2. 神経幹細胞の外部刺激経路による細胞死の分子メカニズムと生物学的役割に関する研究
  3. 体細胞の非遺伝子工学的手法による神経幹細胞の作製法の確立に関する基礎的研究

研究論文
  1. Kotani, M., Sato, Y., Ueno, A., Ito, T., Itoh, K., Imada, M. (2016) A Novel Monoclonal Antibody Against Neuroepithelial and Ependymal Cells and Characteristics of Its Positive Cells in Neurospheres. Cell. Mol. Neurobiol, 36: 11-26.
  2. Itoh, K,. Inamine, M., Oshima, W., Kotani, M., Chiba, Y., Chiba, Y., Ueno, M. and Ishihara, Y. (2015) Prevention of status epilepticus-induced brain edema and neuronal cell loss by repeated treatment with high-dose levetiracetam. Brain Res., 1608: 225-234.
  3. Kotani, M., Itoh, K., Ito, T., Yamashita, T., and Imada, M. (2012) Characterization of a monoclonal antibody, Namu mAb, which reacts to the subventricular zone in mouse brain. NeuroReport, 23:830-834.
  4. Sugawara, T., Kotani, M., Kuramoto, K., Arai, K., Shiraishi, T. and Shoji, T. (2012) Tissue distribution of intravenously administrated insoluble microparticles: Report II. Jpn. J. Pharm. Health Care Sci., 38(9):559-567.
  5. Yokoyama, K., Tezuka, T., Kotani, M., Nakazawa, T., Hoshina, N., Shimoda, Y., Katuta, S., Sudo, K., Watanabe, K., Iwakura, Y., and Yamamoto, T. (2011) NYAP: a phosphoprotein family that links PI3K to WAVE1 signaling in neurons. EMBO J, Sep 23;30(23):4739-4754.
  6. Kubo, H., Kotani, M., Yamamoto, Y., and Hazato, T. (2008) Involvement of sperm proteases in binding of sperm to vitelline envelope in Xenopus laevis. Zoological Science, 25(1):80-87.
  7. Kawashima, I., Ohsawa, M., Fukushige, T., Nagayama, Y., Niida, Y., Kotani, M., Tajima, Y., Kanekura, T., Kanzaki, T., and Sakuraba, T. (2007) Cytochemical analysis of storage materials in cultured skin fibroblasts from patients with I-cell disease. Clin. Chim. Acta, 378(1-2):142-146.
  8. Kotani, M., Okamoto, S., Imada, M., Itoh, K., Irie, A., Sakuraba, H., and Kubo, H. (2007) Flow cytometric analysis of mouse neurospheres based on the expression level of RANDAM-2. Neuroscience Letter, 413(1):25-30.
  9. Sekine, M., Taya, C, Shitara, H., Kikkawa, Y., Akamatsu, N., Kotani, M., Miyazaki, M., Suzuki, A., and Yonekawa, H. (2006) The cis-regulatory element Gs15 is indispensable for straight tubule cell-specific transcription of core 2 beta-1,6-N-acetyl-glucosaminyltransferase in the mouse kidney. J. Biol. Chem., 281:1008-1015.
  10. Sakuraba, H., Murata-Ohsawa, M., Kawashima I., Tajima, Y., Kotani, M., Ohshima, T., Chiba, Y., Takashiba, M., Jigami, Y., Fukushige, T., Kanzaki, T., and Itoh, K. (2006) Comparison of the effects of agalsidase alpha and agalsidase beta on cultured human Fabry fibroblasts and Fabry mice. J. Hum. Genet., 51:180-188.
  11. Sakuraba, S., Chiba, Y., Kotani, M., Kawashima, I., Ohsawa, M., Tajima, Y., Takaoka, Y., Jigami, Y., Takahashi, H., Hirai, Y., Shimada, T., Hashimoto, Y., Kobayashi, T., Eatabe, K., Fukushige, T., and Kanzaki, T. (2006) Corrective effect of yeast recombinant human alpha-galactosidase having N-linked sugar chains suitable for lysosomal delivery on Fabry mice. J. Hum. Genet., 51:341-352.
  12. Oheda, Y., Kotani, M., Murata, M., Sakuraba, H., Kadota, Y., Tatano, Y., Kuwahara, J., and Itoh, K. (2006) Elimination of abnormal sialoglycoproteins in fibroblasts with sialidosis and galactosialidosis by normal gene transfer and enzyme replacement. Glycobiology, 16(4):271-280.
  13. Kawashima, I., Takeuchi, I., Ohsawa, M., Kotani, M., Tajima, Y., Inomata, T., Izumi, T., and Sakuraba, H. (2006) Phospholipid storage in the myocardium of a unique Japanese case of idiopathic cardiomyopathy. Clin. Chim. Acta,372(1-2):154-157.
  14. Watanabe, M., Sakurai, Y., Ichinose, T., Aikawa, Y., Kotani, M., and Itoh, K. (2006) Monoclonal Antibody Rip Specifically Recognizes 2, 3-cyclic nucleotide 3-phosphodiesterase in Oligodendrocytes. J. Neurosci. Res., 84(3):525-533.
  15. Tajima, Y., Uyama, E., Go, S., Sato, C., Tao, N., Kotani, M., Hino, H., Suzuki, A., Sanai, Y., Kitajima, K., and Sakuraba, H. (2005) Distal myopathy with rimmed vacuoles: Impaired O-glycan formation in sarcolemmal glycoproteins. Am. J. Pathol., 166(4): 1121-1130.
  16. Murata, M., Kotani, M., Tajima, Y., Tsuji, D., Ishibashi, Y., Kuroki, A., Itoh, K., Watabe, K., Sango, K., Yamanaka, S., and Sakuraba, H. (2005) Establishment of immortalized Schwann cells from Sandhoff mice and corrective effect of recombinant human beta-hexosaminidase A on the accumulated GM2 ganglioside. J. Hum. Genet., 50:460-467.
  17. Inagaki, S., Migita, M., Hayakawa, M., Fujita, A., Yoshida, J., Ishizaki, M., Kotani, M., Sakuraba, H., Shimada, T., Murakami, M., and Fukunaga, Y. (2005) An asymptomatic heterozygous female with Fabry disease: Implication for enzyme replacement therapy. J. Nippon Med. Sch., 72(6):687-690.

所属学会・団体名
  • 日本生化学会
  • 日本分子生物学会
  • 日本神経科学会
  • 日本薬学会

E-mail

m-kotani@pha.ohu-u.ac.jp