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教員紹介

堀江 均 教授 [Hitoshi Horie]

担当授業科目
  • 微生物学
  • 薬と病態(感染症)
  • 生物学Ⅰ
  • 生物系実習Ⅱ
  • 薬学基礎実習
  • ゲノム創薬概論
  • 特別実習

研究
研究テーマ

感染症の新しい予防方法や治療方法、診断方法の開発を目的とし、主として下痢症や食中毒の原因菌、腸内細菌等を研究対象として、以下の研究を行っています。

  1. 細胞内や生体において病原微生物がどのようにして病原性を発現するか、そのメカニズムの解析
  2. 病原微生物による病原性の発現を分子レベルで制御するための研究
  3. 病原微生物の薬剤耐性化機構の解析と薬剤耐性化阻害に関する研究
  4. 多剤耐性菌の既存抗菌薬に対する再感受性化に関する研究

主な研究論文
  1. Horie H, Tanaka S, Hirano K, Yaegashi A, Yoshida Y et al. Sodium deoxycholate synergistically enhances the antimicrobial activity of β-lactam antibiotics against β-lactamase-producing Staphylococcus aureus. J. Hum. Nurs. Stud. 10: 9-14, 2012.
  2. Nakadate S, Nozawa K, Horie H, Fujii Y and Yaguchi T. New type indole diterpene, Eujindoles, from Eupenicillium javanicum. Heterocycles 83(2): 351-356, 2011.
  3. Igarashi H, Yoshino Y, Miyazawa M, Horie H, Ohka S and Nomoto A. 2A protease is not a prerequisite for poliovirus replication. J. Virol. 84(12): 5947-5957, 2010.
  4. Horie H, Yamahata N, Takahashi N, Yoshida A, Katabami K et al. Enhancement of antimicrobial activities of antibiotics by combination with epigallocatechin gallate against methicillin- resistant Staphylococcus aureus. J. Hum. Nurs. Stud. 7: 19-26, 2009.
  5. Sato H, Taya K, Horie H, Fujii Y and Hamada S. Noni juice made from the fruit of Morinda citrifolia suppresses the growth of oral bacteria and dental caries. Pharmacometrics 75: 117-121, 2008.
  6. Nakadate S, Nozawa K, Sato H, Horie H, Fujii Y et al. Antifungal cyclic depsipeptide, Eujavanicin A, isolated from Eupenicillium javanicum. J. Nat. Prod. 71(9): 1640-1642, 2008.
  7. Sato H, Horie H, Taya K and Hamada S. The antimicrobial activity of cyclopropene derivatives towards oral bacteria. Oral Therap. Pharmacol. 27: 1-7, 2008.
  8. Iwai M, Takizawa T, Nakayama T, Matsuura K, Yoshida H, Hasegawa S, Obara M, Horimoto E, Kurata E and Horie H. Evaluation of a two-dose administration of live oral poliovirus vaccine for wild and virulent vaccine-derived poliovirus type 1, 2, 3 strains in Japan. Scand. J. Infect. Dis. 40: 247-253, 2008.
  9. Horie H and Yamada A. Analysis of the reversion to the neurovirulent genotype in attenuated polio vaccine viruses passaged in cultivation cells derived from the human alimentary tract. J. Hum. Nurs. Stud. 6: 39-47, 2008.
  10. Horie H, Fujii Y, Katabami K, Iwama M and Yamada A. Suppressive effects of traditional herbal medicines on reversion of attenuated polio vaccine viruses to neurovirulent genotype. J. Trad. Med. 24(5): 156-163, 2007.
  11. Nakadate S, Nozawa K, Horie H, Fujii Y, Nagai M et al. Eujavanicols A-C, decalin derivatives from Eupenicillium javanicum. J. Nat. Prod. 70(9): 1510-1512, 2007.
  12. Iwai M, Nakayama T, Matsuura K, Hasegawa S, Ando S, Obara M, Nagai Y, Yoshida H and Horie H. Assessment of efficacy of a live oral poliovirus vaccine for virulent Sabin-like poliovirus 1 strains. Acta Virol. 50: 139-143, 2006.
  13. Yoshikawa T, Iwasaki T, Ida-Hosonuma M, Yoneyama M, Fujita T, Horie H et al. Role of alpha/beta interferon response in the acquisition of poliovirus susceptibility of kidney cells in culture. J. Virol. 80(9): 4313-4325, 2006.
  14. Simizu B, Abe S, Yamamoto H, Tano Y, Ota M, Miyazawa M, Horie H et al. Development of inactivated poliovirus vaccine derived from Sabin strains. Biologicals. 34(2): 151-154, 2006.
  15. Nakadate S, Nozawa K, Horie H, Fujii Y, Nagai M et al. New dioxomorpholine derivatives, javanicunine A and B, from Euprnicillium javanicum. Heterocycles 68(9): 1969-1972, 2006.
  16. Yanagiya A, Jia Q, Ohka S, Horie H and Nomoto A. Blockade of the poliovirus-induced cytopathic effect in neural cells by monoclonal antibody against poliovirus or the human poliovirus receptor. J. Virol. 79(3): 1523-1532, 2005.

総説
  1. 堀江均:ポリオワクチン.「臨床免疫学(下)」日本臨床63巻 増刊号5別冊:p601-606,日本臨床, 2005.

所属学会・団体名
  • 日本生化学会
  • 日本ウイルス学会
  • 日本薬学会

E-mail

h-horie@pha.ohu-u.ac.jp